immunoglobulin class switch recombination deficiencies (ig csr deficiencies) or hyper igm syndromes (higm) are a group of primary immunodeficiency diseases, characterized by defective cd40 signaling of b cells resulting into a csr and a somatic hypermutation. the affected patients are characterized with reduced serum levels of igg and iga, and normal or elevated level of igm, which lead to incr...

A 79-year-old man with a history of dementia and hypertension initially presented with a ten year history of Beau's lines and seasonal nail shedding of his fingernails only. He denied any exposure to heavy metals, unusual activities or food. He stated that the seasonal nail shedding had been occurring for the last 5-10 years. On examination, six out of ten fingernails had been affected. He had ...

Yellow nail syndrome is a rare disease of unclear etiology. We describe a patient who develops yellow nail syndrome, with primary nail and sinus manifestations, shortly after amalgam dental implants. A study of the patient's nail shedding showed elevated nail titanium levels. The patient had her dental implants removed and had complete resolution of her sinus symptoms with no change in her nail...

The nail, a fast-growing organ, is sensitive to changes in the germinal matrix, and, as would be expected, a severe systemic illness can affect the growth rate of the ungual matrix, which occasionally results in temporary growth arrest (Beau’s line). Thus, recovery from growth arrest can be associated with onychomadesis, also called nail shedding, a condition that indicates the separation of th...

OBJECTIVE To report an unusual reaction associated with weekly administration of paclitaxel. CASE SUMMARIES Onycholysis was seen in four women with recurrent ovarian cancer being treated with low-dose, weekly paclitaxel. Two of the patients had previously received higher doses of paclitaxel on an every-three-week schedule without similar reactions. Onycholysis developed between weeks 10-13 of...

Hand-foot-mouth disease (HFMD) is caused by enterovirus or Coxsackie virus (CV) infection. It is characterized by palmoplantar vesiculopustular eruption and erosive stomatitis [1], which enables differential diagnosis from herpangina, aphthous stomatitis, and Kawasaki disease. There are several case reports on the nail presentation of HFMD [1-10], but some clinicians are not yet familiar with t...

Yellow nail syndrome was defined in 1964 as a combination of slow growing, discoloured nails and edema (Samman & White, 1964). The rate of growth of finger nails was less than 0.2 mm per week compared with the normal 0.5-1.2 mm per week. The nails were thickened and the cuticles were deficient. The color varied from pale yellow to slightly greenish. Onycholysis (separation of the nail from its ...

During fall 2008, an outbreak of hand, foot, and mouth disease (HFMD) with onychomadesis (nail shedding) as a common feature occurred in Finland. We identified an unusual enterovirus type, coxsackievirus A6 (CVA6), as the causative agent. CVA6 infections may be emerging as a new and major cause of epidemic HFMD.

Beau lines are transverse, band-like depressions extending from one lateral edge of the nail to the other and affecting all nails at corresponding levels (1). Onychomadesis is considered an extreme form of Beau line with subsequent separation of the proximal nail plate from the nail bed. Both fall along a spectrum of nail plate abnormalities that occur secondary to temporary nail matrix arrest ...